Ii summary inherited susceptibility to cancer due to germline mutations causes of inherited susceptibility to colorectal cancer familial adenomatous polyposis hereditary nonpolyposis colorectal cancer. Lecture 20 cancer genetics discovery and innovation. The series is sponsored by the national human genome research institute nhgri, in collaboration with suburban hospital and johns hopkins university school of medicine. He was awarded the nobel prize for that work in 1968. It covers clinical practice of physicians, genetic counselors, and nutritionists, clinical diagnostic laboratory activities, and research into the causes and inheritance of genetic disorders. The partial nucleotide sequence of each exon is shown, with deletions indicated by red dashed lines and missense mutations shown in red and underlined. Get information about genetic counseling, familial cancer syndromes, genomic sequencing, germline and somatic testing, ethical and legal issues and more in this summary for clinicians.
Padmini moffett presents genitourinary cancers with a quick overview on the different types of cancer like prostate cancer, renal cell carcinoma, bladder cancer, and testicular cancer as well as the risk factors for these types of cancers. Several viruses are now linked to cancer in humans, for example. I will introduce many names of genes and proteins, but there will be a fair amount of repetition throughout the series of lectures, so you can expect to see the same diagrams more than once. Apoptosis and cancer genetics same as lecture 34 handout sex determination and dosage compensation. Read more about markey clinical trials allow our researchers to do the research that can help heal kentuckians and move the entire state forward. I think mike cruickshanks new profit maximiser service is going to be one of the big hits and i can say hand on heart, if you follow the instructions, and just get. The genetics of cancer a presentation by angelee, skyler, and jerri. Although cancer is complex, and environmental and other nongenetic factors clearly play a role in many stages of the neoplastic process, the tremendous progress made in understanding tumorigenesis in large part is owing to the discovery of the genes, that when mutated, lead to cancer. Sawyers presents an overview of cancer biology and describes how understanding the molecular mechanisms involved in one type of cancer, chronic myeloid leukemia, resulted in the development of gleevec, one of the first targeted cancer drugs. This eightlecture series by top experts in oncology and genomics will enhance healthcare professionals understanding of the intersection between genomics. Genetics and prevention of cancer approximately one in three people in the uk will develop cancer during their lifetime. Ppt genetics lecture powerpoint presentation free to.
Mutations in cancer genes transform normal cells into cancer cells oncogenes gene that makes a cell cancerous dominant gainoffunction mutations tumor suppressor genes genes that normally restrain growth recessive, lossoffunction mutations mutator genes spont. Add to your lists send you email reminders further detail subscribe using icalvcal the main aim of this lecture series is to provide all researchers with a strong background in cancer biology, ranging from basic biology through to translational aspects. Cancer genetics overview discusses hereditary cancers and the role of genetic variants mutations. The 202014 genomics in medicine lecture series nhgri. Related titles from bmj books abc of antenatal care abc of labour care abc of the first year. Cell proliferation results in a mass that invades neighboring tissues and may metastasize to more distant sites. Why cancer matters new cancer cases in 1997 cancer deaths in 1997. The department of cancer genetics and genomics, through the investigation of the various mechanisms that cells adopt to become cancer cells, is dedicated to improving our understanding of mechanisms and pathways through which cells overcome their normal constraints on. Alterations in different kinds of genes cause cancer oncogenes dominant gainoffunction mutations promote cell transformation. Supercourse lectures in pptpdf format university of pittsburgh. Apr 17, 2019 the first in our lecture series for michaelmas term 2014, given in the jcr at mansfield college by professor stephen jones emeritus professor of genetics, university college london.
Cancer arises through a series of somatic alterations in dna that result in unrestrained cellular proliferation. This lecture is held on the first thursday of each month at 4. The talks are accompanied by powerpoint slides and cover the basics of cancer biology. The documents were created using microsoft word, and are probably best viewed if opened in word. Cancer genomics lecture anvita gupta february 11, 2016 introduction to cancer all of us start from one cell, called the zygote. The journal prioritizes analyses performed at the molecular and cellular level that reveal novel mechanistic insight into pathways and processes linked to cancer risk, development, andor progression. Gruber, md, phd november 18, 2002 cancer is, in essence, a genetic disease. Fred bunz of johns hopkins school of medicine, provides a a very nice introduction to modern cancer genetics. Each lecture was held at suburban hospitals lower level auditorium at 8600 old georgetown road in bethesda, md. Lecture 1 intro to genetics 20% genetic disease classic medical genetics, single gene, early onset pediatric 80% genetic susceptibility common gene variation and environment, delayed onset adult pedigree children, siblings, parents nuclear family agedate birth, health status, agedate death, cause of death. Genomics course biochemistry and molecular genetics. Cancer genetic counseling and testing services are available in canada. Among lfs family members who inherit an abnormal p53 gene,approx 50% will develop invasive cancer by age 30 and more than 90% will develop invasive cancer by age 70. Michael ratner memorial lecture series mrm is a nonprofit organization that presents valuable health, medicine and science related speakers to the chicago community including physicians, nurses, healthcare providers, families, patients, caregivers and the community in general.
This talk is from a 20 holiday lecture series, medicine in the genomic era. Alterations in different kinds of genes cause cancer oncogenes dominant gainoffunction mutations promote cell transformation tumor suppressor genes recessive, lossoffunction mutations promote cell transformation mutator genes. In order for a normal cell to transform into a cancer cell, genes which regulate cell growth and differentiation must be altered. In this lecture, i will outline the cancer course but i will also go into some detail on basic concepts. Jan 03, 2018 2017 was the year of genetherapy breakthroughs. This eight lecture series by top experts in oncology and genomics will enhance healthcare professionals understanding of the intersection between genomics and medicine. Dec 06, 2019 the 2020 rule of thumb genetics of oncogenestsgs. Cancer genetics genetic instability free download as powerpoint presentation. Breast cancer cancer cases particularly high grade serous male breast cancer. Bevin engelward, mit biological engineering department. Kopchicks lectures powerpoint slides from previous years. Ppt genetics lecture powerpoint presentation free to view. A free powerpoint ppt presentation displayed as a flash slide show on id. May 04, 2017 st vincents clinical school is proud to present a lecture on psychosocial and ethical aspects of genomic medicine by maryanne young, sophie devery and tatiane yanes.
Cancer geneticsgenetic instability free download as powerpoint presentation. St vincents clinical school is proud to present a lecture on psychosocial and ethical aspects of genomic medicine by maryanne young, sophie devery and tatiane yanes. Age at first skin cancer 100 90 80 70 60 50 40 30 20 10 0 0 10 xp population nonxp population 20 30 40 50 60 age years cumulative cancer incidence % 70 80 90 figure by mit ocw. Pdf of original pdf of presentation ppt presentation posted. It is appropriate for advanced undergraduates and graduate students, as well as medical students.
Although cancer is complex, and environmental and other nongenetic factors clearly play a role in many stages of the neoplastic process, the tremendous progress made. Apply genetics in medical care and involves the diagnosis and management of hereditary disorders. Eukaryotic gene organization, re, vectors lecture 3. We began by reminding everyone that exam 3 is scheduled for tuesday, november 12, covering all lecture material following exam 2. Lecture 21 cancer genetics i lecture 21 cancer genetics i stephen b.
The human genome project hgp was an international year. The genetic nature of cancer cancer is a complex disease that result from the basic process of uncontrolled growth. From science in the modern world to the genetics of diabetes. Molecular and human genetics baylor college of medicine. One of the two dna strands, the template strand, provides a template for ordering the sequence of complementary nucleotides in an rna transcript.
Ammonia is an end product of amino acid metabolism and is converted in the liver to urea through a series of enzymatic reactions termed the urea. This zygote then divides into two more cells, which then divide again, eventually producing the billions of cells that make up our bodies. The 20112012 genomics in medicine lecture series nhgri. The longerlived the organism, the more likely it is that one cell eventually will lose the ability to collaborate with its neighbors in maintaining structure and function, and just start multiplying. Longstanding infection with the hepatitis b or c viruses can lead to cancer of the liver. Cancer genetics overview pdqhealth professional version. Heres the link to this awesome free video about how to cure gout in 7 days or less 100% naturally. Genefixing treatments have now cured a number of patients with cancer and rare diseases. Cell cycle, apoptosis and cancer genetics same as lecture 34 handout sex determination and dosage compensation same file as a pdf sex determination and dosage compensation same as lecture 37 handout developmental genetics morphogens same file as a pdf developmental genetics cellcell signaling same as lecture 39 handout. Cancer genetics and genomics roswell park comprehensive. Genetics of cancer lecture 35 tumor suppressors, dna. She will explain how her group aims to find genes that. Mutations in the somatic cells are not transferred to the progeny but are important in the.
Welcome to week 2 objectives evaluate the concepts of genetics, genomics and cancer todays topics. Introduction to systems biology of cancer lecture 1. Scribd is the worlds largest social reading and publishing site. Bio4241 advanced topics in genetics memorial university. Cancer metabolism welcome institute for cancer genetics. The first in our lecture series for michaelmas term 2014, given in the jcr at mansfield college by professor stephen jones emeritus professor of genetics, university college london. What types of genetic changes turn a normal cell into a cancer cell.
Column1 unknown brca12 other high penetrance moderate penetrance known snps predicted snp 0. Elaine ostrander, chief and senior investigator in nhgris cancer genetics branch, studies genes important in growth regulation, particularly as it pertains to disease states in humans and canines. Genetics of cancer alterations in the cell cycle and gene mutations that cause cancer how do we define cancer. Chlorine molecules already in the atmosphere will continue to influence ozone levels for at least 50 years. As kentuckys only ncidesignated center, the uk markey cancer center is equipped to provide worldclass cancer care. For more information about syndromes see our hereditary colorectal cancer powerpoint educational module 1. Jul, 2012 the 20112012 genomics in medicine lecture series the inaugural genomics in medicine lecture series was sponsored by nhgri, in collaboration with suburban hospital and johns hopkins. This eightlecture series by top experts in oncology and genomics will enhance healthcare professionals understanding of the intersection between genomics and medicine. Pierce genetics a conceptual approach sixth edition chapter 23 cancer genetics cancer. Cancer genetics harrisons principles of internal medicine, 20e. Lecture 20 cancer genetics november 5, 20 introduction. The vast majority 9095% of cancers occur by chance as the end result of. A small number of resources have been developed that can be used to introduce trainees to the ethics surrounding genetic testing for hereditary breast and ovarian cancer, 16 noninvasive prenatal testing for singlegene disorders, 17 preimplantation genetic diagnoses, 18 the clinical utility of whole exome or genome sequencing, 19 nondirective. Powerpoint slide on cancer genetics compiled by monika saini.
Although cancer is complex, and environmental and other nongenetic factors clearly play a role in many stages of the neoplastic process, the tremendous progress made in understanding tumorigenesis in. The writing is lucid and concise, and the many figures and diagrams. The series is sponsored by the national human genome research institute nhgri, in collaboration with suburban hospital and johns hopkins university school of medici. Elaine ostrander, chief and senior investigator in nhgris cancer genetics branch, studies genes important in growth regulation, particularly as it pertains to. Cancer is a group of disorders that causes cells to escape normal controls on cell division cancer cells divide more frequently cancer cells are not inhibited by contact with other cells and can form tumors cancer cells can invade other tissues, a process called metastasis spread. This new book on cancer genetics, written in its entirety by dr. As understanding of the genetic basis of human disease has grown, genetic testing applications for these conditions have grown in parallel. An international agreement signed in 1987 has resulted in a decrease in ozone depletion.
Cancer genetics online medicine course lecturio online. Pierce genetics a conceptual approach sixth edition chapter 23 cancer genetics cancer is fundamentally a genetic disorder. Cancer uncontrolled cellular proliferation cancer is a genetic disease about 510% caused by inherited genetic mutations majority by cumulative effect of somatic mutations cancer is a disease of cell cycle. During the human lifetime, there are 10 million billion cell divisions and each division represents, as robert weinberg puts it, an opportunity for disaster, for chaos to occur. Clinical trials allow our researchers to do the research that. Ozone depletion causes dna damage in plants and phytoplankton. An interlocking u and k to the left of the word healthcare. Click on any lecture title to download a copy of the course handout for that day.
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